Title : Celecoxib inhibits production of MMP and NO via down-regulation of NF-kappaB and JNK in a PGE2 independent manner in human articular chondrocytes.

Pub. Date : 2008 Jun

PMID : 18080123






2 Functional Relationships(s)
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1 Celecoxib at 100 nM reduced the IL-1beta-induced productions of MMP-1, MMP-3, iNOS, and NO, whereas indomethacin at 100 nM showed no effect. Celecoxib matrix metallopeptidase 1 Homo sapiens
2 Celecoxib has inhibitory effects on MMP-1, MMP-3 and NO productions, suggesting the protective roles directly on articular chondrocytes. Celecoxib matrix metallopeptidase 1 Homo sapiens