Title : Phosphorylated ITIMs enable ubiquitylation of an inhibitory cell surface receptor.

Pub. Date : 2008 Feb

PMID : 18062779






1 Functional Relationships(s)
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1 Here, we show, using CD33/sialic acid-binding immunoglobulin-like lectin (Siglec)-3 as a paradigm, that ITIMs can bind to the ubiquitin ligase Cbl and that ITIMs are ubiquitylated following Src family kinase-mediated tyrosine phosphorylation. Tyrosine CD33 molecule Homo sapiens