Title : The G2 p38-mediated stress-activated checkpoint pathway becomes attenuated in transformed cells.

Pub. Date : 2007 Dec 18

PMID : 18060783






2 Functional Relationships(s)
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1 Because the primary substrate of p38, the MK2 kinase, is also transiently (1-2 hr) activated by anisomycin in both normal and cancer cells, checkpoint disruption in transformed cells occurs downstream of MK2. Anisomycin MAPK activated protein kinase 2 Homo sapiens
2 Because the primary substrate of p38, the MK2 kinase, is also transiently (1-2 hr) activated by anisomycin in both normal and cancer cells, checkpoint disruption in transformed cells occurs downstream of MK2. Anisomycin MAPK activated protein kinase 2 Homo sapiens