Pub. Date : 2008 Feb
PMID : 18042668
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vivo regulation of phenylalanine hydroxylation to tyrosine, studied using enrichment in apoB-100. | Phenylalanine | apolipoprotein B | Homo sapiens |
| 2 | A new and more sensitive method to measure label enrichment in proteins using isotope ratio mass spectrometry demonstrated that phenylalanine hydroxylation measured in apoB-100 decreased linearly in response to increasing tyrosine intake and reached a break point at 6.8 mg.kg(-1).day(-1). | Phenylalanine | apolipoprotein B | Homo sapiens |
| 3 | We conclude: apoB-100 is an accurate and useful measure of changes in phenylalanine hydroxylation; the synthesis of tyrosine via phenylalanine hydroxylation is regulated to meet the needs for protein synthesis; and that plasma phenylalanine does not reflect changes in protein synthesis. | Phenylalanine | apolipoprotein B | Homo sapiens |