Title : Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity.

Pub. Date : 2008 Jan 25

PMID : 18035049






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Folylpolyglutamate synthase and gamma-glutamyl hydrolase regulate leucovorin-enhanced 5-fluorouracil anticancer activity. Leucovorin gamma-glutamyl hydrolase Homo sapiens
2 We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV. Leucovorin gamma-glutamyl hydrolase Homo sapiens
3 We investigated the roles of folylpolyglutamate synthase (FPGS) and gamma-glutamyl hydrolase (GGH), which are the main enzymes involved in folate metabolism, in the effect of LV. Leucovorin gamma-glutamyl hydrolase Homo sapiens
4 These results suggest that FPGS and GGH expression levels in tumors are determinants of the efficacy of LV in enhancing the antitumor activity of 5-FU. Leucovorin gamma-glutamyl hydrolase Homo sapiens