Pub. Date : 2007 Oct
PMID : 18007078
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Effect of rosiglitazone on NO and eNOS via PI3K/PKB signal pathways in cultured human umbilical vein endothelial cells]. | Rosiglitazone | protein tyrosine kinase 2 beta | Homo sapiens |
| 2 | OBJECTIVE: To observe the effect of rosiglitazone on the production of nitric oxide (NO) and the expression of phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) /the endothelial nitric oxide synthase (eNOS) in cultured human umbilical vein endothelial cells(HUVECs), and to investigate the mechanism of signal transduction of rosiglitazone in improving the endothelial function. | Rosiglitazone | protein tyrosine kinase 2 beta | Homo sapiens |
| 3 | RESULTS: Rosiglitazone increased the endothelial NO production in a dose- and time-dependent manner in cultured HUVECs, and also increased the expression of PI3K mRNA and the phosphorylation of PKB-Ser473 and eNOS-Ser1177 in a concentration-dependent manner, with no alteration in the expression of PKB and eNOS in cultured HUVECs. | Rosiglitazone | protein tyrosine kinase 2 beta | Homo sapiens |
| 4 | RESULTS: Rosiglitazone increased the endothelial NO production in a dose- and time-dependent manner in cultured HUVECs, and also increased the expression of PI3K mRNA and the phosphorylation of PKB-Ser473 and eNOS-Ser1177 in a concentration-dependent manner, with no alteration in the expression of PKB and eNOS in cultured HUVECs. | Rosiglitazone | protein tyrosine kinase 2 beta | Homo sapiens |
| 5 | N(w)-nitro-L- arginine methyl ester (L-NAME, eNOS synthase inhibitor) blocked the rosiglitazone-induced NO formation; LY294002 (a PI3K inhibitor) prevented the NO production; and the phosphorylation of eNOS and PKB was induced by rosiglitazone. | Rosiglitazone | protein tyrosine kinase 2 beta | Homo sapiens |
| 6 | CONCLUSION: Treatment with rosiglitazone can increase the NO production and improve the endothelial function through up-regulating the PI3K/PKB/eNOS signal pathways in cultured HUVECs. | Rosiglitazone | protein tyrosine kinase 2 beta | Homo sapiens |