Title : O2*- and NO-associated mechanisms of selective action of redox-active cobalt complexes on tumor tissue.

Pub. Date : 2007 Sep

PMID : 18004245






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 CONCLUSION: It is supposed that the one of mechanisms of detected earlier antimetastatic effect of complex is based on its ability to induce the formation of high level of superoxide radical-anions selectively in the tumor tissue that results in the damage of its regulatory functions, in particular alteration in the regulation of NO-synthase, decrease of NO generation as well as activities of MMPs. Superoxides matrix metallopeptidase 2 Mus musculus