Title : Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene.

Pub. Date : 2008 Mar

PMID : 18000088






4 Functional Relationships(s)
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1 RESULTS: We found that the C allele of a single nucleotide polymorphism in the STK11 gene (expressed in liver; also known as LKB1) was associated with a significantly decreased chance of ovulation in PCOS women treated with metformin. Metformin serine/threonine kinase 11 Homo sapiens
2 RESULTS: We found that the C allele of a single nucleotide polymorphism in the STK11 gene (expressed in liver; also known as LKB1) was associated with a significantly decreased chance of ovulation in PCOS women treated with metformin. Metformin serine/threonine kinase 11 Homo sapiens
3 CONCLUSIONS: We have demonstrated that a polymorphism in STK11, a kinase gene expressed in liver and implicated in metformin action, is associated with ovulatory response to treatment with metformin alone in a prospective randomized trial. Metformin serine/threonine kinase 11 Homo sapiens
4 CONCLUSIONS: We have demonstrated that a polymorphism in STK11, a kinase gene expressed in liver and implicated in metformin action, is associated with ovulatory response to treatment with metformin alone in a prospective randomized trial. Metformin serine/threonine kinase 11 Homo sapiens