Title : Restoration of a regulatory response to low density lipoprotein in acid lipase-deficient human fibroblasts.

Pub. Date : 1976 Jun 10

PMID : 179993






1 Functional Relationships(s)
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1 The acquisition of this acid lipase activity enhanced the ability of the Wolman Syndrome and Cholesteryl Ester Storage Disease cells to respond to the lipoprotein by suppression of 3-hydroxy-3-methylglutaryl coenzyme A reductase and activation of cellular cholesteryl ester formation. Cholesterol Esters 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens