Pub. Date : 2007 Dec
PMID : 17996206
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of confluence on beta-catenin dephosphorylation was prevented by down regulation of nSMase2 using siRNA; reciprocally, exogenous addition of short or very long chain ceramides induced dephosphorylation of beta-catenin. | Ceramides | sphingomyelin phosphodiesterase 3 | Homo sapiens |
| 2 | All together these results establish: A) a specific intracellular pathway involving the activation of PP1 to mediate the effects of confluence-induced beta-catenin dephosphorylation and B) PP1 as a lipid-regulated protein phosphatase downstream of nSMase2/ceramide. | Ceramides | sphingomyelin phosphodiesterase 3 | Homo sapiens |