Title : Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization.

Pub. Date : 2008 Jan 18

PMID : 17993459






1 Functional Relationships(s)
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1 The neuroprotective effect of leptin is antagonized by the JAK2-STAT3 inhibitor AG-490, STAT3 decoy DNA, and phosphatidylinositol 3-kinase/Akt inhibitors but not by an inhibitor of MAPK. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide leptin Mus musculus