Pub. Date : 2007
PMID : 17990952
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Therefore, we hypothesized that Hcy activates AT1 receptor that potentiates STAT3 via ERK-1/2 phosphorylation. | Homocysteine | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | RESULTS: Although Hcy dose-dependently induced AT1 receptor expression in the endothelial cells, a significant induction was observed at 100 microM at 48 h. We investigated Hcy-induced ERK-1/2 and STAT3 phosphorylation through AT1 receptor induction, and our results suggest that Hcy activated AT1 receptor which led to ERK-1/2 and STAT3 phosphorylation. | Homocysteine | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | RESULTS: Although Hcy dose-dependently induced AT1 receptor expression in the endothelial cells, a significant induction was observed at 100 microM at 48 h. We investigated Hcy-induced ERK-1/2 and STAT3 phosphorylation through AT1 receptor induction, and our results suggest that Hcy activated AT1 receptor which led to ERK-1/2 and STAT3 phosphorylation. | Homocysteine | mitogen-activated protein kinase 3 | Mus musculus |