Title : On-chip oligonucleotide ligation assay using one-dimensional microfluidic beads array for the detection of low-abundant DNA point mutations.

Pub. Date : 2008 Feb 28

PMID : 17983740






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1 In this paper, an on-chip oligonucleotide ligation approach that arrayed a series of functionalized beads in a single microfluidic channel was described for detection of low-abundant point mutations in p53 gene. Oligonucleotides tumor protein p53 Homo sapiens