Title : Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.

Pub. Date : 2008 Jun

PMID : 17983653






1 Functional Relationships(s)
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1 In this study, we found that AZD6244 (ARRY-142886), a novel inhibitor of MEK1/2 kinases, effectively inhibited the proliferation of acute biphenotypic leukemia MV4-11 and acute monocytic leukemia MOLM13 cells. AZD 6244 mitogen-activated protein kinase kinase 1 Homo sapiens