Pub. Date : 2007 Dec
PMID : 17982682
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Erythropoietin reduces cisplatin-induced neurotoxicity without impairment of cytotoxic effects against tumor cells. | Cisplatin | erythropoietin | Homo sapiens |
| 2 | Since erythropoietin, a hematopoietic growth factor that corrects chemotherapy-induced anemia, reduces transfusion requirements and seems to improve the patient"s quality of life, has been shown to exert cytoprotective effects we decided to investigate its direct influence on cisplatin-induced neurotoxicity against primary cortical neurons isolated from rats. | Cisplatin | erythropoietin | Homo sapiens |
| 3 | We observed that pre-treatment of neurons with erythropoietin significantly protects these cells from cisplatin-induced cytotoxicity. | Cisplatin | erythropoietin | Homo sapiens |
| 4 | Similarly to erythropoietin, a selective ERK1/2 inhibitor significantly reduced cisplatin-induced cytotoxicity against neuronal cells. | Cisplatin | erythropoietin | Homo sapiens |
| 5 | Altogether our studies confirm that erythropoietin might be an effective cytoprotective agent that reduces cisplatin-induced neurotoxicity. | Cisplatin | erythropoietin | Homo sapiens |