Title : Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.

Pub. Date : 2007 Nov

PMID : 17980631






2 Functional Relationships(s)
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1 Here, we revealed the antagonistic interplay between Ikaros and its associate the chromatin remodeler Mi-2beta during T cell development, as exemplified by the regulation of Cd4 expression. ikaros chromodomain helicase DNA binding protein 4 Homo sapiens
2 In double-positive thymocytes, concomitant binding of Mi-2beta with Ikaros to the Cd4 silencer caused silencer inactivation, thereby allowing for CD4 expression. ikaros chromodomain helicase DNA binding protein 4 Homo sapiens