Pub. Date : 2007 Oct
PMID : 17979764
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Functional regulation of hepatic cytochrome p450 enzymes by physicochemical properties of phospholipids in biological membranes. | Phospholipids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | P450 is a membrane-anchored protein that shows a variety of interaction with membrane phospholipids, which affect the membrane topology and catalytic activities of the protein. | Phospholipids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | In particular, anionic phospholipids, nonbilayer forming lipids, and the degree of saturation of the lipid fatty acyl chain play important roles in the functional regulation of P450, as well as in the bilayer structure of the membrane. | Phospholipids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | However, despite the importance of phospholipids in the regulation of P450s, the interaction of the protein with membrane phospholipids, and the membrane properties induced by phospholipids which regulate P450, are unclear. | Phospholipids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | In this review, we describe the effect of the physicochemical properties of the phospholipid constituents of biological membranes on hepatic P450 catalytic activity, membrane insertion (and/or penetration), and structural changes. | Phospholipids | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |