Title : Genetic variation in the cytochrome P450 epoxygenase pathway and cardiovascular disease risk.

Pub. Date : 2007 Oct

PMID : 17979511






2 Functional Relationships(s)
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1 The cytochrome (CYP) P450 epoxygenase pathway catalyzes the epoxidation of arachidonic acids to epoxyeicosatrienoic acids, which are subsequently hydrolyzed to less active dihydroxyeicosatrienoic acids by soluble epoxide hydrolase. epoxyeicosatrienoic acids peptidylprolyl isomerase G Homo sapiens
2 Numerous preclinical studies have demonstrated that CYP-derived epoxyeicosatrienoic acids possess potent vasodilatory and anti-inflammatory properties in the cardiovascular system. epoxyeicosatrienoic acids peptidylprolyl isomerase G Homo sapiens