Title : Prazosin displays anticancer activity against human prostate cancers: targeting DNA and cell cycle.

Pub. Date : 2007 Oct

PMID : 17971903






1 Functional Relationships(s)
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1 In p53-null PC-3 cells, prazosin induced an increase in DNA strand breaks and ATM/ATR checkpoint pathways, leading to the activation of downstream signaling cascades, including Cdc25c phosphorylation at Ser216, nuclear export of Cdc25c, and cyclin-dependent kinase (Cdk) 1 phosphorylation at Tyr15. Prazosin tumor protein p53 Homo sapiens