Title : Regulation of platelet-derived growth factor receptor activation by afadin through SHP-2: implications for cellular morphology.

Pub. Date : 2007 Dec 28

PMID : 17971444






1 Functional Relationships(s)
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1 Upon binding of platelet-derived growth factor (PDGF), PDGF receptor is autophosphorylated at tyrosine residues in its cytoplasmic region, which induces the activation of diverse intracellular signaling pathways such those involving Ras-ERK, c-Src, and Rap1-Rac. Tyrosine thymoma viral proto-oncogene 1 Mus musculus