Title : Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer.

Pub. Date : 2007 Nov

PMID : 17965220






3 Functional Relationships(s)
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1 METHODS: PKC isoform expression was examined in tamoxifen responsive, oestrogen receptor positive (ER(+)), ER(+) acquired tamoxifen resistant (TAM-R) and oestrogen receptor negative (ER(-)) cell lines by western blotting and immunocytochemical analysis. Tamoxifen proline rich transmembrane protein 2 Homo sapiens
2 METHODS: PKC isoform expression was examined in tamoxifen responsive, oestrogen receptor positive (ER(+)), ER(+) acquired tamoxifen resistant (TAM-R) and oestrogen receptor negative (ER(-)) cell lines by western blotting and immunocytochemical analysis. Tamoxifen proline rich transmembrane protein 2 Homo sapiens
3 Patients showing a PKC-delta(+)/PKC-alpha(-) phenotype had a six times longer endocrine response than patients with the PKC-delta(+)/ PKC-alpha(+) phenotype (equating to tamoxifen resistance in vitro). Tamoxifen proline rich transmembrane protein 2 Homo sapiens