Title : Role of pregnane X receptor in control of all-trans retinoic acid (ATRA) metabolism and its potential contribution to ATRA resistance.

Pub. Date : 2008 Feb

PMID : 17962516






2 Functional Relationships(s)
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1 In addition to pregnenolone 16alpha-carbonitrile, several clinically relevant PXR ligands (rifampicin and dexamethasone) all increased ATRA metabolism both in vitro and in vivo, which was PXR-dependent, and up-regulation of Cyp3a was the major contributor. Rifampin nuclear receptor subfamily 1, group I, member 2 Mus musculus
2 In addition to pregnenolone 16alpha-carbonitrile, several clinically relevant PXR ligands (rifampicin and dexamethasone) all increased ATRA metabolism both in vitro and in vivo, which was PXR-dependent, and up-regulation of Cyp3a was the major contributor. Rifampin nuclear receptor subfamily 1, group I, member 2 Mus musculus