Title : Functional characterization of Mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space.

Pub. Date : 2007 Dec 28

PMID : 17959605






4 Functional Relationships(s)
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1 We have characterized the redox behavior of Mia40p and reconstituted the disulfide transfer system of Mia40p by using recombinant functional C-terminal fragment of Mia40p, Mia40C, and Erv1p. Disulfides growth factor, augmenter of liver regeneration Homo sapiens
2 In the course of this reaction, mixed disulfides of Mia40C and Erv1p were formed. Disulfides growth factor, augmenter of liver regeneration Homo sapiens
3 In the reconstituted system the thiol oxidase Erv1p was sufficient to transfer disulfide bonds to Mia40C, which then could oxidize the variant of Mia40C. Disulfides growth factor, augmenter of liver regeneration Homo sapiens
4 In summary, we reconstituted a disulfide relay system consisting of Mia40C and Erv1p. Disulfides growth factor, augmenter of liver regeneration Homo sapiens