Title : Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.

Pub. Date : 2007 Nov 1

PMID : 17947653






1 Functional Relationships(s)
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1 Recent studies showed that the expression and function of human TCR was improved by the introduction of an additional disulfide bond between the alpha- and beta-chains or by the exchange of the human constant region for murine sequences. Disulfides T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens