Title : Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism.

Pub. Date : 2008 Jan

PMID : 17947222






1 Functional Relationships(s)
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1 BACKGROUND: Tamoxifen is hydroxylated by cytochrome P450 (CYP) 2D6 to the potent metabolites 4-hydroxytamoxifen (4OHtam) and 4-hydroxy-N-demethyltamoxifen (4OHNDtam), which are both conjugated by sulphotransferase (SULT)1A1. hydroxytamoxifen sulfotransferase family 1A member 1 Homo sapiens