Pub. Date : 1991 Dec
PMID : 1794603
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Methimazole and propylthiouracil increase thyroglobulin gene expression in FRTL-5 cells. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 2 | In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 3 | In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 4 | In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 5 | In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 6 | In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 7 | In FRTL-5 cells, methimazole (MMI) and propylthiouracil (PTU), both thyroid peroxidase (TPO) inhibitors, increase thyroglobulin (Tg) mRNA levels and Tg accumulation in the medium. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 8 | An increase in Tg mRNA levels and in Tg accumulation was observed after 2-4 h and 8 h incubation with 10,000 microM MMI or PTU, respectively. | Propylthiouracil | thyroglobulin | Rattus norvegicus |
| 9 | An increase in Tg mRNA levels and in Tg accumulation was observed after 2-4 h and 8 h incubation with 10,000 microM MMI or PTU, respectively. | Propylthiouracil | thyroglobulin | Rattus norvegicus |