Title : Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway.

Pub. Date : 2007 Oct

PMID : 17938270






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Moreover, epothilone B and D increased the expressions of NF-kappaB-dependent apoptotic cell death regulatory genes, i.e., Bax, p53, and the active form of caspase-3, but reduced Bcl-2 expression, and these actions were partially reversed by salicylic acid. epothilone B caspase 3 Homo sapiens
2 In addition, caspase-3 inhibitor reduced epothilone B-induced cell death and NF-kappaB activation. epothilone B caspase 3 Homo sapiens