Title : Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene.

Pub. Date : 2007 Nov 7

PMID : 17935701






6 Functional Relationships(s)
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1 Distributions of glucuronyltransferases, GlcAT-P and GlcAT-S, and their target substrate, the HNK-1 carbohydrate epitope in the adult mouse brain with or without a targeted deletion of the GlcAT-P gene. Carbohydrates beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus
2 It is known that the HNK-1 carbohydrate is synthesized through two key enzymes, glucuronyltransferases (GlcAT-P and GlcAT-S). Carbohydrates beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus
3 It was shown histologically that the localization of HNK-1 carbohydrate paralleled the pattern of expression of GlcAT transcripts in the brain. Carbohydrates beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus
4 Additionally, the localization of HNK-1 carbohydrate was restricted partially in the brain of GlcAT-P-deficient mice, while the HNK-1 carbohydrate was widely distributed over most of the brain of wild-type mice. Carbohydrates beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus
5 Additionally, the localization of HNK-1 carbohydrate was restricted partially in the brain of GlcAT-P-deficient mice, while the HNK-1 carbohydrate was widely distributed over most of the brain of wild-type mice. Carbohydrates beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus
6 The present study provides a new framework for understanding the network constructed by the HNK-1 carbohydrate in the central nervous system. Carbohydrates beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P) Mus musculus