Title : Fish cardiac sodium channels are tetrodotoxin sensitive.

Pub. Date : 2007 Nov

PMID : 17935523






2 Functional Relationships(s)
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Protein Name
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1 AIM: Sodium current (I(Na)) of the mammalian heart is resistant to tetrodotoxin (TTX) due to low TTX affinity of the cardiac sodium channel (Na(v)) isoform Na(v)1.5. Tetrodotoxin immunoglobulin lambda variable 2-18 Homo sapiens
2 More surprisingly, omNa(v)1.5a also has an aromatic tyrosine in this position, instead of the cysteine of the mammalian TTX-resistant Na(v)1.5. Tetrodotoxin immunoglobulin lambda variable 2-18 Homo sapiens