Title : Expression of human O6-methylguanine-DNA methyltransferase in Chinese hamster ovary cells and restoration of cellular resistance to certain N-nitroso compounds.

Pub. Date : 1991

PMID : 1793486






2 Functional Relationships(s)
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Protein Name
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1 Transfection of this plasmid into Chinese hamster ovary (CHO) cells results in expression of MGMT and in cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and 1-(2-chloroethyl)-1-nitrosourea (CNU), but not to N-nitroso-N-ethylurea. 1-(2-chloroethyl)-1-nitrosourea methylated-DNA--protein-cysteine methyltransferase Cricetulus griseus
2 Transfection of this plasmid into Chinese hamster ovary (CHO) cells results in expression of MGMT and in cellular resistance to N-methyl-N"-nitro-N-nitrosoguanidine (MNNG) and 1-(2-chloroethyl)-1-nitrosourea (CNU), but not to N-nitroso-N-ethylurea. 1-(2-chloroethyl)-1-nitrosourea methylated-DNA--protein-cysteine methyltransferase Cricetulus griseus