Title : Tuning of the outer hair cell motor by membrane cholesterol.

Pub. Date : 2007 Dec 14

PMID : 17933870






6 Functional Relationships(s)
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1 To study the effects of cholesterol on hearing at the molecular level, we altered cholesterol levels in the OHC wall, which contains the membrane protein prestin. Cholesterol solute carrier family 26 member 5 Homo sapiens
2 We show a dynamic and reversible relationship between membrane cholesterol levels and voltage dependence of prestin-associated charge movement in both OHCs and prestin-transfected HEK 293 cells. Cholesterol solute carrier family 26 member 5 Homo sapiens
3 We show a dynamic and reversible relationship between membrane cholesterol levels and voltage dependence of prestin-associated charge movement in both OHCs and prestin-transfected HEK 293 cells. Cholesterol solute carrier family 26 member 5 Homo sapiens
4 Cholesterol levels also modulate the distribution of prestin within plasma membrane microdomains and affect prestin self-association in HEK 293 cells. Cholesterol solute carrier family 26 member 5 Homo sapiens
5 Cholesterol levels also modulate the distribution of prestin within plasma membrane microdomains and affect prestin self-association in HEK 293 cells. Cholesterol solute carrier family 26 member 5 Homo sapiens
6 These findings indicate that alterations in membrane cholesterol affect prestin function and functionally tune the outer hair cell. Cholesterol solute carrier family 26 member 5 Homo sapiens