Title : Anti-diol epoxide of benzo[a]pyrene induces transient Mdm2 and p53 Ser15 phosphorylation, while anti-diol epoxide of dibenzo[a,l]pyrene induces a nontransient p53 Ser15 phosphorylation.

Pub. Date : 2008 Apr

PMID : 17932951






2 Functional Relationships(s)
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1 In this study, we have characterized the effect of the ultimate carcinogenic DEs, (+)-anti-BPDE and (-)-anti-DBPDE following short exposure times, on Mdm2 and p53 pathway in A549 human lung epithelial carcinoma cells. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens
2 (+)-anti-BPDE-induced effects on Mdm2 were transient and correlated with transient p53 Ser15 phosphorylation. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide tumor protein p53 Homo sapiens