Pub. Date : 2008 Jan 15
PMID : 17919121
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 2 | Polyamines are required for maintenance of intestinal epithelial integrity, and a decrease in cellular polyamines increases the cytoplasmic levels of RNA-binding protein HuR stabilizing p53 and nucleophosmin mRNAs, thus inhibiting IEC (intestinal epithelial cell) proliferation. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 3 | Here, we provide evidence showing that polyamines modulate subcellular localization of HuR through AMPK-regulated phosphorylation and acetylation of Impalpha1 (importin alpha1) in IECs. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 4 | AMPK activation by overexpression of the AMPK gene increased Impalpha1 but reduced the cytoplasmic levels of HuR in control and polyamine-deficient cells. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 5 | Ectopic expression of these Impalpha1 mutants also prevented the increased levels of cytoplasmic HuR following polyamine depletion. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 6 | These results indicate that polyamine-mediated AMPK activation triggers HuR nuclear import through phosphorylation and acetylation of Impalpha1 in IECs and that polyamine depletion increases cytoplasmic levels of HuR as a result of inactivation of the AMPK-driven Impalpha1 pathway. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 7 | These results indicate that polyamine-mediated AMPK activation triggers HuR nuclear import through phosphorylation and acetylation of Impalpha1 in IECs and that polyamine depletion increases cytoplasmic levels of HuR as a result of inactivation of the AMPK-driven Impalpha1 pathway. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |
| 8 | These results indicate that polyamine-mediated AMPK activation triggers HuR nuclear import through phosphorylation and acetylation of Impalpha1 in IECs and that polyamine depletion increases cytoplasmic levels of HuR as a result of inactivation of the AMPK-driven Impalpha1 pathway. | Polyamines | ELAV like RNA binding protein 1 | Homo sapiens |