Title : The multikinase inhibitor sorafenib potentiates TRAIL lethality in human leukemia cells in association with Mcl-1 and cFLIPL down-regulation.

Pub. Date : 2007 Oct 1

PMID : 17909059






1 Functional Relationships(s)
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1 Sorafenib/TRAIL-induced cell death was accompanied by mitochondrial injury and release of cytochrome c, Smac, and AIF into the cytosol and caspase-9, caspase-3, caspase-7, and caspase-8 activation. Sorafenib apoptosis inducing factor mitochondria associated 1 Homo sapiens