Pub. Date : 2007 Oct 1
PMID : 17909004
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 2 | In the present study, microsomes of UGT2B10-overexpressing HEK293 cells exhibited high N-glucuronidation activity against both nicotine and cotinine with apparent KM"s that were 37- and 3-fold lower than that observed for microsomes of UGT1A4-overexpressing cells against nicotine and cotinine, respectively. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 3 | In the present study, microsomes of UGT2B10-overexpressing HEK293 cells exhibited high N-glucuronidation activity against both nicotine and cotinine with apparent KM"s that were 37- and 3-fold lower than that observed for microsomes of UGT1A4-overexpressing cells against nicotine and cotinine, respectively. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 4 | The KM of microsomes from wild-type (WT) UGT2B10-overexpressing cells for nicotine and cotinine was similar to that observed for human liver microsomes (HLM) against both substrates. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 5 | These data suggest that UGT2B10 is the major hepatic enzyme involved in nicotine/cotinine glucuronidation and that the UGT2B10*2 variant significantly reduces nicotine- and cotinine-N-glucuronidation formation and plays an important role in nicotine metabolism and elimination. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 6 | These data suggest that UGT2B10 is the major hepatic enzyme involved in nicotine/cotinine glucuronidation and that the UGT2B10*2 variant significantly reduces nicotine- and cotinine-N-glucuronidation formation and plays an important role in nicotine metabolism and elimination. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 7 | These data suggest that UGT2B10 is the major hepatic enzyme involved in nicotine/cotinine glucuronidation and that the UGT2B10*2 variant significantly reduces nicotine- and cotinine-N-glucuronidation formation and plays an important role in nicotine metabolism and elimination. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |
| 8 | These data suggest that UGT2B10 is the major hepatic enzyme involved in nicotine/cotinine glucuronidation and that the UGT2B10*2 variant significantly reduces nicotine- and cotinine-N-glucuronidation formation and plays an important role in nicotine metabolism and elimination. | Cotinine | UDP glucuronosyltransferase family 2 member B10 | Homo sapiens |