Title : Arsenic salt-induced DNA damage and expression of mutant p53 and COX-2 proteins in SV-40 immortalized human uroepithelial cells.

Pub. Date : 2007 Nov

PMID : 17906315






3 Functional Relationships(s)
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1 In addition, the expression of mutant p53 increased in parallel with comet scores, and the maximal expression of mutant p53 was observed at 4 microM arsenite. arsenite tumor protein p53 Homo sapiens
2 In addition, the expression of mutant p53 increased in parallel with comet scores, and the maximal expression of mutant p53 was observed at 4 microM arsenite. arsenite tumor protein p53 Homo sapiens
3 This study provides us with knowledge of the relationship between p53 and COX-2 over-expression in arsenite-treated urothelial cells and suggests a potential therapeutic role of COX-2 inhibitors in human urothelial malignancies. arsenite tumor protein p53 Homo sapiens