Pub. Date : 2007 Sep
PMID : 17898873
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In cultured 9L gliosarcoma cells, AQP1 expression was induced by dexamethasone, platelet-derived growth factor, NaCl, hypoxia, D-glucose (but not L-glucose), and fructose. | Glucose | aquaporin 1 (Colton blood group) | Homo sapiens |
| 2 | Induction of AQP1 expression correlated with the level of glycolysis, maximized by increasing medium D-glucose or fructose and decreasing O(2), and was quantified by measuring lactate dehydrogenase (LDH) activity and medium lactate concentration. | Glucose | aquaporin 1 (Colton blood group) | Homo sapiens |
| 3 | Increased glucose metabolism at the tumor periphery may provide a scenario by which upregulation of AQP1, LDH, and cathepsin B contributes to acidification of the extracellular milieu and to invasive potential of glioma cells in perivascular space. | Glucose | aquaporin 1 (Colton blood group) | Homo sapiens |