Title : KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae.

Pub. Date : 2007 Nov 23

PMID : 17893149






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 KEG1/YFR042w encodes a novel Kre6-binding endoplasmic reticulum membrane protein responsible for beta-1,6-glucan synthesis in Saccharomyces cerevisiae. beta-1,6-glucan Keg1p Saccharomyces cerevisiae S288C
2 Immunoprecipitation from the Triton X-100-solubilized cell lysate revealed that Keg1 binds to Kre6, which has been known to participate in beta-1,6-glucan synthesis. beta-1,6-glucan Keg1p Saccharomyces cerevisiae S288C
3 The keg1-1 mutant cells showed a common phenotype with Deltakre6 mutant including hypersensitivity to Calcofluor white, reduced sensitivity to the K1 killer toxin, and reduced content of beta-1,6-glucan in the cell wall. beta-1,6-glucan Keg1p Saccharomyces cerevisiae S288C
4 These results suggest that Keg1 and Kre6 have a cooperative role in beta-1,6-glucan synthesis in S. cerevisiae. beta-1,6-glucan Keg1p Saccharomyces cerevisiae S288C