Title : Differential role of CYP2E1-mediated metabolism in the lethal and vestibulotoxic effects of cis-crotononitrile in the mouse.

Pub. Date : 2007 Dec 15

PMID : 17878057






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 We conclude that cis-crotononitrile is a CYP2E1 substrate as hypothesized, but that CYP2E1-mediated metabolism of this nitrile is not necessary for vestibular toxicity; rather, this metabolism constitutes a major pathway for cyanide release and subsequent lethality. Cyanides cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus