Title : Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors.

Pub. Date : 2007 Sep 15

PMID : 17875730






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 By using mice transgenic for human CD16A, enhanced survival was observed due to expression of CD16A-158(phe) on monocytes and macrophages as well as on NK cells in these mice. Phenylalanine Fc gamma receptor IIIa Homo sapiens
2 By using mice transgenic for human CD16A, enhanced survival was observed due to expression of CD16A-158(phe) on monocytes and macrophages as well as on NK cells in these mice. Phenylalanine Fc gamma receptor IIIa Homo sapiens