Title : The role of growth hormone and cortisone on glucose and gluconeogenic substrate regulation in fasted hypopituitary children.

Pub. Date : 1976 May

PMID : 178683






2 Functional Relationships(s)
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1 With cortisone plus GH therapy, fasting glycemia was improved (73 +/- 6 mg/dl) at 30 hours fasting and was associated with increased alanine and glutamine concentrations (206 +/- 28 muM and 448 +/- 40 muM, respectively) and less ketonemia (beta-hydroxybutyrate 1.13 +/- 0.39 mM). Glutamine growth hormone 1 Homo sapiens
2 We suggest that the hypoglycemia observed in hypopituitary patients is a substrate-mediated phenomenon, and that cortisone and growth hormone replacement therapy improve fasting glucose homeostasis, increase circulating alanine and glutamine concentrations, and decrease hepatic gluconeogenesis. Glutamine growth hormone 1 Homo sapiens