Title : Platelet-derived growth factor-induced stabilization of cyclooxygenase 2 mRNA in rat smooth muscle cells requires the c-Src family of protein-tyrosine kinases.

Pub. Date : 2007 Nov 9

PMID : 17855367






4 Functional Relationships(s)
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Protein Name
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1 Site-directed mutagenesis of putative tyrosine phosphorylation sites in CUGBP2 identified tyrosine 39 as a c-Src target, and a CUGBP2 with a mutated tyrosine 39 displayed an attenuated ability to bind COX-2 mRNA. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
2 Site-directed mutagenesis of putative tyrosine phosphorylation sites in CUGBP2 identified tyrosine 39 as a c-Src target, and a CUGBP2 with a mutated tyrosine 39 displayed an attenuated ability to bind COX-2 mRNA. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
3 Site-directed mutagenesis of putative tyrosine phosphorylation sites in CUGBP2 identified tyrosine 39 as a c-Src target, and a CUGBP2 with a mutated tyrosine 39 displayed an attenuated ability to bind COX-2 mRNA. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus
4 Therefore, our data suggest that tyrosine phosphorylation of CUGBP2 is an important underlying mechanism for the ability of PDGFR/c-Src signaling to control the stability of COX-2 mRNA. Tyrosine SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus