Title : Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma.

Pub. Date : 2007 Oct

PMID : 17854307






1 Functional Relationships(s)
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1 In addition to ERK inhibition, NFATc1 (nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1) and c-fos were both downregulated, suggesting that AZD6244 targets a later stage of OCL differentiation. AZD 6244 Fos proto-oncogene, AP-1 transcription factor subunit Homo sapiens