Title : Calpain counteracts mechanosensitive apoptosis of vascular smooth muscle cells in vitro and in vivo.

Pub. Date : 2008 Feb

PMID : 17846083






3 Functional Relationships(s)
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1 Apoptosis was prevented by the p53 inhibitor pifithrin and by p53 antisense oligonucleotides, indicating dependency of force-induced apoptosis on p53. Oligonucleotides tumor protein p53 Homo sapiens
2 Apoptosis was prevented by the p53 inhibitor pifithrin and by p53 antisense oligonucleotides, indicating dependency of force-induced apoptosis on p53. Oligonucleotides tumor protein p53 Homo sapiens
3 Prevention of calpain activation by calpeptin or antisense oligonucleotides augmented strain-induced p53 expression and transcriptional activity, resulting in a further increase of apoptotic rate. Oligonucleotides tumor protein p53 Homo sapiens