Title : Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts.

Pub. Date : 2007 Nov 3

PMID : 17825250






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Y27632, a specific inhibitor of Rho-kinase, significantly suppressed the IL-6 synthesis induced by ET-1 as well as the MYPT-1 phosphorylation. Y 27632 endothelin 1 Mus musculus
2 Y27632 as well as fasudil attenuated the ET-1-induced phosphorylation of p38 MAP kinase but not p44/p42 MAP kinase. Y 27632 endothelin 1 Mus musculus