Title : Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase.

Pub. Date : 2007 Nov

PMID : 17766468






3 Functional Relationships(s)
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1 Since 3-NT accumulation was diminished 3- to 20-fold in heart, lung, and liver in ApoE(-/-) mice missing iNOS, iNOS-derived species are involved in this reaction. 3-nitrotyrosine nitric oxide synthase 2, inducible Mus musculus
2 Since 3-NT accumulation was diminished 3- to 20-fold in heart, lung, and liver in ApoE(-/-) mice missing iNOS, iNOS-derived species are involved in this reaction. 3-nitrotyrosine nitric oxide synthase 2, inducible Mus musculus
3 These findings demonstrate that iNOS-derived species are increased during atherogenesis in ApoE(-/-) mice and that these species differentially contribute to protein 3-NT accumulation and BH(4) oxidation in a tissue-selective manner. 3-nitrotyrosine nitric oxide synthase 2, inducible Mus musculus