Title : In vitro and in vivo characterization of the non-peptide NK3 receptor antagonist SB-223412 (talnetant): potential therapeutic utility in the treatment of schizophrenia.

Pub. Date : 2008 Jun

PMID : 17728699






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 Functionally, talnetant competitively antagonized neurokinin B (NKB)-induced responses at the human recombinant receptor in both calcium and phosphoinositol second messenger assay systems (pA2 of 8.1 and 7.7, respectively). phosphoinositol tachykinin precursor 3 Homo sapiens
2 Functionally, talnetant competitively antagonized neurokinin B (NKB)-induced responses at the human recombinant receptor in both calcium and phosphoinositol second messenger assay systems (pA2 of 8.1 and 7.7, respectively). phosphoinositol tachykinin precursor 3 Homo sapiens