Pub. Date : 2008 Jan
PMID : 17722069
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERK1 plays a critical protective role against N-methyl-D-aspartate-induced retinal injury. | N-Methylaspartate | mitogen-activated protein kinase 3 | Mus musculus |
| 2 | Here we describe a previously unknown role for retinal glial cells in NMDA-induced retinal injury that involves the activation of ERK1/2. | N-Methylaspartate | mitogen-activated protein kinase 3 | Mus musculus |
| 3 | Within 1 hr after injecting NMDA intravitreally, activation of ERK1/2 and c-Fos induction were observed in retinal Muller cells. | N-Methylaspartate | mitogen-activated protein kinase 3 | Mus musculus |
| 4 | NMDA-induced ERK1/2 activation in retina was significantly suppressed in ERK1(-/-) mice, and these mice had significantly higher numbers of TUNEL-positive retinal cells than wild-type mice 24 hr after NMDA injection. | N-Methylaspartate | mitogen-activated protein kinase 3 | Mus musculus |
| 5 | NMDA-induced ERK1/2 activation in retina was significantly suppressed in ERK1(-/-) mice, and these mice had significantly higher numbers of TUNEL-positive retinal cells than wild-type mice 24 hr after NMDA injection. | N-Methylaspartate | mitogen-activated protein kinase 3 | Mus musculus |