Title : Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells.

Pub. Date : 2008 Mar 1

PMID : 17721990






2 Functional Relationships(s)
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1 Pretreatment with nitric oxide (NO) scavengers could inhibit 5 microM MG/20 mM glucose-induced cytochrome c release, decrease activation of caspase-9 and caspase-3, and increase the gene expression and protein levels of p53 and p21, which are known to be involved in apoptotic signaling. Glucose tumor protein p53 Homo sapiens
2 Inhibition of p53 protein expression using small interfering RNA (siRNA) blocked the activation of p21 and the cell apoptosis induced by 5 microM MG/20 mM glucose. Glucose tumor protein p53 Homo sapiens