Pub. Date : 2007 Jul
PMID : 17718444
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | [Real-time PCR used to detect p53 gene damage in workers exposed to arsenic]. | Arsenic | tumor protein p53 | Homo sapiens |
| 2 | OBJECTIVE: To evaluate the relationship between the metabolism of arsenic and the damage of exon 5 and 8 of p53 gene from workers in a arsenic mill, and with real-time PCR technique, to establish the method probing the gene-specific DNA damage in people. | Arsenic | tumor protein p53 | Homo sapiens |
| 3 | OBJECTIVE: To evaluate the relationship between the metabolism of arsenic and the damage of exon 5 and 8 of p53 gene from workers in a arsenic mill, and with real-time PCR technique, to establish the method probing the gene-specific DNA damage in people. | Arsenic | tumor protein p53 | Homo sapiens |
| 4 | METHODS: By real-time PCR, the damages of exon 5 and 8 of p53 gene were probed in 37 workers exposed highly to, 16 manager and logistic employees exposed less to an arsenic mill in Yunnan province, and also 25 local people who did not contact with any white arsenic in near past time. | Arsenic | tumor protein p53 | Homo sapiens |
| 5 | METHODS: By real-time PCR, the damages of exon 5 and 8 of p53 gene were probed in 37 workers exposed highly to, 16 manager and logistic employees exposed less to an arsenic mill in Yunnan province, and also 25 local people who did not contact with any white arsenic in near past time. | Arsenic | tumor protein p53 | Homo sapiens |
| 6 | The correlation between metabolism of arsenic and damage of p53 gene was evaluated. | Arsenic | tumor protein p53 | Homo sapiens |
| 7 | The Ct relative value of exon 5 of p53 gene in high exposed group was higher than that in control male (P < 0.05), and the increased tendency of Ct relative value of exon 5 of p53 gene was found in workers with organic arsenic concentration going up (r(s) = 0.355, P = 0.011). | Arsenic | tumor protein p53 | Homo sapiens |
| 8 | The Ct relative value of exon 5 of p53 gene in high exposed group was higher than that in control male (P < 0.05), and the increased tendency of Ct relative value of exon 5 of p53 gene was found in workers with organic arsenic concentration going up (r(s) = 0.355, P = 0.011). | Arsenic | tumor protein p53 | Homo sapiens |
| 9 | CONCLUSION: The damages in exon 5 and 8 of p53 gene in workers exposed to arsenic may be induced. | Arsenic | tumor protein p53 | Homo sapiens |